What questions should the nurse ask to establish the patient’s risk for noncompliance?

A home care nurse is seeing an 81 years old man who is taking a complex medication regimen. He cannot remember when he last took several of his medications, and his wife states she is confused by the recent switch of several drugs to other generic brands. What questions should the nurse ask to establish the patient’s risk for noncompliance? What are the nurse responsibilities in the case?